C:\Users\<username>\AppData\Roaming\Notepad++\shortcuts.xml
%SystemRoot%\sysnative\WindowsPowerShell\v1.0\powershell.exe -noexit '$(FULL_CURRENT_PATH)' -verbose
Note that the single-quotes help when there are spaces in the file path.
%SystemRoot%\sysnative\WindowsPowerShell\v1.0\powershell.exe -noexit ; python $(FULL_CURRENT_PATH)
%SystemRoot%\sysnative\WindowsPowerShell\v1.0\powershell.exe -noexit ; cd '$(CURRENT_DIRECTORY)' ; robot.bat $(FULL_CURRENT_PATH)